Paravastu, Venkata Kamala Kumari <br/><br/>
Application of Box-Behnken Design for Formulation Parameters of Eslicarbazepine Tablets 

 - Vol.83(3), May-June 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 575-583p. 
<br/><br/> Current research has been done to develop statistically and optimized immediate release tablets for<br/>eslicarbazepine. Nineteen formulations of eslicarbazepine acetate immediate release tablets are prepared<br/>by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed to study<br/>how selected independent variables affect dependent responses. After the initial test, three independent<br/>items were selected as follows; polyvinylpyrrolidone (A), tapioca starch (B) and galbanum gum (C).<br/>Responses to measure were the time of disintegration (Y1) and in vitro drug release at 45 min (Y2). In<br/>accordance with the independent variables, three different levels were established as the lowest, highest<br/>and middle variables tested. The predicted formula formulated with the Box-Behnken statistical design<br/>consisted of polyvinylpyrrolidone, tapioca starch and galbanum gum at the optimum levels of 2.49, 2.77<br/>and 3 respectively. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS