VENKATALAKSHMI, P. <br/><br/>
In vivo Immunomodulatory Potential of Aqueous Extract of Different Parts of Terminalia catappa L. 

 - Vol.83(3), May-June 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 584-593p. 
<br/><br/> Modulation of immunity is the most sought therapeutic effect as many human ailments arise because of<br/>imbalance in immune mechanisms. In the current corona virus disease scenarios also, the role of immunity<br/>to combat the dreadful virus has been well emphasized. Hence the present study aims at evaluating the<br/>immunomodulatory potential of aqueous extract obtained from the different parts such as bark, fruit and<br/>wood of Terminalia catappa. Based on the results obtained in acute oral toxicity and dose fixation studies,<br/>medium dose (250 mg/kg body weight) of selected plant extracts were administered for 14 d to swiss albino<br/>mice to evaluate nonspecific (neutrophil adhesion, phagocytic index) and specific (hemagglutination<br/>antibody titer, delayed type hypersensitivity) immunomodulatory properties. The results obtained for<br/>plant extract treated groups were compared with cyclophosphamide (immunosuppressant) treated and<br/>levamisole (immunostimulant) treated mice. From the data of the results obtained it could be concluded<br/>that selected parts ofTerminalia catappa have immune stimulatory as well as anti-inflammatory properties,<br/>thereby proving their efficacy as true immunomodulators. Among the parts selected, fruits exhibited<br/>significant immunomodulatory potential followed by bark and wood. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS