KWON, DA AE  <br/><br/>
Standardized Extract (HemoHIM) from Angelica gigas Nakai, Cnidium officinale Makino and Paeonia lactiflora Pallas Extract Attenuates Acetaminophen-Induced Liver Injury in Human Hepatocellular Carcinoma Cells and Mice Model 

 - Vol.83(2), March-April 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 195-203p. 
<br/><br/> In this study, the hepatoprotective e ffects of the herbal preparation (HemoHIM) against acetaminophen-<br/>induced liver injury were investigated in vitro and in vivo. We investigated the messenger Ribonucleic acid<br/>expression of antioxidant factors and proinflammatory cytokines in human hepatocellular carcinoma cells<br/>treated with acetaminophen. In vivo study, Institute of Cancer Research mice was divided intofive groups<br/>(n=10): control, acetaminophen, HemoHIM 250, 500 mg/kg body weight and silymarin 200 mg/kg body<br/>weight, respectively. Mice were administrated acetaminophen (350 mg/kg body weight) on d 5 after sample<br/>administration. Blood samples were collected for aspartate aminotransferase, alanine transaminase<br/>assessment. Liver tissue was determined for glutathione, triglyceride, cholesterol and histopathological<br/>features. HemoHIM has significant effects in the treatment groups compared to acetaminophen group. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS