KARAN, S.  <br/><br/>
Bioactive Compounds and Antimicrobial Activity of Glasswort Salicornia europaea 

 - Vol.83(2), March-April 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 238-246p. 
<br/><br/> This study aims to determine the chemical and physical composition and antibacterial activity of<br/>glasswort. Soxhlet extraction of Salicornia europaea was performed using hexane and analyzed by<br/>Gas chromatography-mass spectrometry. Alpha-tocopherol content was analysed by using liquid<br/>chromatography with tandem mass spectrometry. The elemental analysis was investigated by inductively<br/>coupled plasma mass spectrometry. The crystallographic texture and composition of powder samples were<br/>determined by X-ray diffraction. The minimum inhibition concentrations and inhibition zones extracts of<br/>Salicornia europaeawere performed by spectrophotometric broth microdilution and disc diffusion methods,<br/>respectively, against 4 bacteria ( Escherichia coli , Klebsiella pneumonia , Bacillus subtilis , Staphylococcus<br/>aureus) and 2 fungi (Candida albicans, Candida parapsilosis). Alpha-tocopherol quantity and oil content of<br/>Salicornia europaea were found to be 2.1±0.3 mg/100 g and 15.15 %, respectively. The detected minerals<br/>were also found as sodium 447, magnesium 51.98, K 45.86, Ca 14.27 ppm. The highest minimum inhibition<br/>concentration was 0.9 mg/ml against Escherichia coli in methanol extract (p ˂0.05). The highest mean<br/>inhibition zones diameter was 3.8 mm for methanol extracts against Bacillus subtilis (p˂0.05). As a result,<br/>the extract and oil of Salicornia europaea can be used as potential bioactive and antimicrobial agents for<br/>pharmaceutical and cosmetics applications 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS