RAGHAVENDRA, H. L. <br/><br/>
Understanding Pharmacodynamics of Butyl Isobutyl Phthalate: Where In vitro and In silico Studies Converge 

 - Vol.83(2), March-April 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 271-277p. 
<br/><br/> Recent epidemiological studies suggest that postprandial hyperglycemia is an independent risk factor for<br/>cardiovascular disease. A human’s high carbohydrate diet majorly consists of a high carbohydrate diet<br/>and α-glucosidase is a glucosidase located in the brush border of the small intestine is involved in glycosidic<br/>cleavage of starch at α-glycosidic bonds. α-glucosidase inhibitors are a unique class of anti-diabetic<br/>drugs particularly useful in individuals with a high carbohydrate diet. α-glucosidase inhibitors works by<br/>competitively inhibiting the enzymeα-glucosidase at the brush border of the small intestines, thus delaying<br/>the digestion of complex carbohydrate and intestinal absorption of glucose. Hence, in the present study,<br/>the α-glucosidase inhibition activity of butyl isobutyl phthalate isolated from chloroform fraction ofRubus<br/>steudneri leaves investigated and its possible mechanism of action ascertained in silico . The compound<br/>was found to exhibit concentration-dependent inhibition of α-glucosidase with half-maximal inhibitory<br/>concentration value of 10.68 g/ml. The results of in vitro α-glucosidase inhibition assay for butyl isobutyl<br/>phthalate were promising and substantiated by molecular docking and molecular dynamics studies. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS