Yarraguntla, S. R. <br/><br/>
Simultaneous estimation of solifenacin succinate and tamsulosin hydrochloride in combined dosage form by using first order derivative spectrophotometric method 

 - Vol.83(2), March-April 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 331-335p. 
<br/><br/> Using first-order derivative techniques, a simple accurate and precise Ultraviolet spectrophotometric<br/>method was developed for the determination of solifenacin succinate and tamsulosin hydrochloride in<br/>combined dosage form. Every soli finacin succinate and tamsulosin hydrochloride was scanned in the<br/>wavelength region of 200-400 nm for determination of sampling wavelengths and selected sampling<br/>wavelengths were selected. Sampling wavelengths were chosen at 265 nm (zero crossing of soli finacin<br/>succinate) where the absorbance of tamsulosin hydrochloride was important and at 250 nm (zero crossing<br/>of tamsulosin hydrochloride) where the absorbance of solifinacin succinate was significant. For solifenacin<br/>succinate, linearity ranged from 10 to 100 μg/ml with a correlation coe fficient of 0.998 and 2 to 10 μg/ml<br/>for the correlation coefficient of tamsulosin hydrochloride is 0.9988. The median recovery was considered<br/>to be satisfactory. For the routine study of solifenacin succinate and tamsulosin hydrochloride in combined<br/>dosage forms, the approach proposed can be applie. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS