Prajapat, Manisha

Update on geographical variation and distribution of SARS‑nCoV‑2: A systematic review - Vol.53(4), July-Aug - Mumbai Wolter Kluwer 2021 - 310-316p.

Knowledge of a new mutant strain of SARS‑coronavirus (CoV‑2) is enormously essential to identify
a targeted drug and for the development of the vaccine. In this article, we systematically reviewed
the different mutation strains (variant of concern [VOC] and variant of interest [VOI]) which were
found in different countries such as the UK, Singapore, China, Germany, Vietnam, Western Africa,
Dublin, Ireland, Brazil, Iran, Italy, France, America, and Philippines. We searched four literature
databases (PubMed, EMBASE, NATURE, and Willey online library) with suitable keywords and the
time filter was November 2019 to June 16, 2021. To understand the worldwide spread of variants
of SARS‑CoV‑2, we included a total of 27 articles of case reports, clinical and observational studies
in the systematic review. However, these variants mostly spread because of their ability to increase
transmission, virulence, and escape immunity. So, in this paper is we found mutated strains of
SARS‑CoV‑2 like VOCs that are found in different regions across the globe are ALPHA strain in the
U.K, BETA strain in South Africa, GAMMA strain in Brazil, Gamma and Beta strains in European
Countries, and some VOIs like Theta variant in the Philippines.


PHARMACOLOGY