Unique synthesis of isochromenoindolone via reductive-oxidative cyclisation approach
- Vol.58(B), Jan.
- New Delhi CSIR 2021
- 104-108p.
Fused heterocyclic compounds are extensively studied in medicinal chemistry due to their promising biological properties such as anticancer, antiviral, antimicrobial activities, etc.1-4 Such compounds also find a resemblance to the constituent structures of important natural products5-9 (Figure 1). Indole and isochromane based heterocyclic structures are found in several medicinally important compounds hence a fused convergent structural motif promises interesting biological properties10-13. Isochromenoindolone is one such compound with probable lead to a new class of bioactive compounds14−17. Anticipating a vast potential for medicinal studies for this compound, we directed our efforts towards developing a simple, efficient and versatile method for synthesis of isochromeno[4,3- b]indol-5(11H)-one.