Kadam, Hari K.

Unique synthesis of isochromenoindolone via reductive-oxidative cyclisation approach - Vol.58(B), Jan. - New Delhi CSIR 2021 - 104-108p.

Fused heterocyclic compounds are extensively studied
in medicinal chemistry due to their promising
biological properties such as anticancer, antiviral,
antimicrobial activities, etc.1-4 Such compounds also
find a resemblance to the constituent structures of
important natural products5-9 (Figure 1).
Indole and isochromane based heterocyclic
structures are found in several medicinally important
compounds hence a fused convergent structural motif
promises interesting biological properties10-13.
Isochromenoindolone is one such compound with
probable lead to a new class of bioactive
compounds14−17. Anticipating a vast potential for
medicinal studies for this compound, we directed our
efforts towards developing a simple, efficient and
versatile method for synthesis of isochromeno[4,3-
b]indol-5(11H)-one.


GENERAL CHEMISTRY