Yachi, Qurrata Ayuni Lubakisar <br/><br/>
Immunomodulator activity of mangiferin from mango (mangifera indica l.) in cancer: a systematic review 

 - Vol.13(10) 
 - M P  Innovare Academic Sciences Pvt Ltd  2021 
 - 7-11p. 
<br/><br/> Cancer is a disease that is causing an increase in mortality all over the world. Cancer treatment is expensive and has a variety of side effects. Natural compound  treatment  is  an  attempt  to  reduce  the  side  effects  of  cancer  therapy.  Mangiferin  is  a  natural  compound  with  anticancer  and  immunomodulatory activity. The immunomodulatory activity of mangiferin from mango (Mangifera indicaL.) in cancer was discussed in this article. The  literature  used  in  this  review  was  obtained  from  several  databases,  including the  Cochrane  Library,  Google  Scholar,  PubMed,  ProQuest,  ScienceDirect, and the Wiley Online Library, for articles published over the last ten years. Mangiferin  influenced  anticancer  activity  by  inhibiting  NF-κB, affects the regulation of β-catenin,  EMT,  MMP2,  MMP9,  LDH,  NO,  ROS,  and  inhibits  classical macrophages activation.Mangiferin has an immunomodulatory effect that can be developed as a candidate drug for anticancer therapy. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS