Tiwari, Ruchi <br/><br/>
Non-conventional therapy of lethal pneumonia symptoms and viral activity of sars-cov-2 during cov-id-19 infection using bee venom compound, melittin  : ahypothesis 

 - Vol.53(4), April 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 14-20p. 
<br/><br/> Suggested cell entry mechanisms of SARS-CoV-2 are binding of S1 protein present on spikes of SARS-CoV-2 with the cell surface of<br/>hACE2 and S-protein priming by the serine protease, Transmembrane Serine Protease 2 (TMPRSS2) and cysteine protease, Cathepsin<br/>B and L (Cat B/L). Melittin is the primary constituent of Apis mellifera, the European honeybee poison which acts as an anti-cancer,<br/>anti-microbial, anti-viral, anti-diabetic and anti-inflammatory agent. Reports suggested that Melittin can directly lyse the viral membrane,<br/>may act as Serine Protease inhibitor and is able to inhibit aggregation of membrane proteins and thus can reduce the pneumonia-like<br/>symptoms during SARS-CoV-2 infection. Herein, we discuss the potential use of Melittin to subside pneumonia-like symptoms and act<br/>as an anti-viral agent in the early stages of COVID-19 treatment. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS