Attar, U. A.  <br/><br/>
Proximate composition, ionomics, phytochemical, antioxidant, anti-diabetic and acetylcholinesterase inhibitory activity of cucumis species from western ghats of India 

 - Vol.83(4), July-Aug 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 679-694p. 
<br/><br/> The present study was intended to evaluate nutrition and antioxidant potential of four Cucumis species<br/>from the Western Ghats of India. All the studied Cucumis species were found to be an excellent source<br/>of nutraceuticals. Leaves and fruits of Cucumis indicus were rich source of energy (296.84±0.20 and<br/>333.52±0.15 kcal/100 g respectively) and several minerals. Cucumis maderaspatanus exhibited the highest<br/>flavonoids, tannins and terpenoids along with highest antioxidant potential. Chemometric analysis<br/>highlighted the influence of phytochemicals on the antioxidant activities from the organic and aqueous<br/>solvents extracts of four Cucumis species, wherein organic extracts found superior. Ethanolic leaf and fruit<br/>extracts of Cucumis maderaspatanus demonstrated highest alpha-amylase inhibitory activity (58.58±0.63<br/>and 45.43±0.27 % at 1 mg extract). Similar trend was observed for alpha-glucosidase inhibition from the<br/>fruit extract of maderaspatanus (74.31±3.75 % at 100 μg extract). Acetone fruit extract of Cucumis indicus<br/>revealed the highest acetylcholinesterase inhibitory activity (31.63±0.16 % at 100 μg extract). Further,<br/>extensive research work is needed to explore the Cucumis species as functional food to manage diabetes<br/>mellitus and Alzheimer’s diseases. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS