Sahu, R.  <br/><br/>
Recent development in nuclear magnetic resonance as a technique for quantitative method validation 

 - Vol.83(6), Nov-Dec 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 1094-1106p. 
<br/><br/> Nuclear magnetic resonance spectroscopy has largely given way for most important routine analysis<br/>of natural, synthetic drug candidate and related molecules. The quality control and simultaneous<br/>quantitation of different residual solvents, analytes and impurities have led analysts to further exploit<br/>nuclear magnetic resonance as a viable quantitative technique. Hence, this review focuses on the use<br/>and feasibility of this technique for quantitative method validation of drug and related compounds.<br/>Validated quantitative nuclear magnetic resonance methods were simple, robust, accurate and selective<br/>for evaluating different natural and synthetic samples using various commercially accessible compounds<br/>as internal standards. In this review numerous examples are cited giving proof of advancement in nuclear<br/>magnetic resonance technology and also for precise evaluation of molecular structures of substances in<br/>solids and liquid. Studied examples of different concurrent validation methods in the review shows that<br/>the results obtained is precise with less standard deviation when compared with other chromatography<br/>techniques. Concluding the entire review, various methodologies used for quantification and validations<br/>were reflected that proved to be a specific, selective and alternative means of method validation and it can<br/>be summarized that nuclear magnetic resonance is as reliable as the chromatography-based technique for<br/>quantitative analysis providing accuracy. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS