Eshwar, Shruthi  <br/><br/>
Histological assessment of fucoidan gelatine chitosan compound injectable hydrogel for bone regeneration in wistar rats 

 - Vol.83(6), Nov-Dec 
 - Mumbai  Indian Journal of Pharmaceutical Science  2021 
 - 1254-1260p. 
<br/><br/> To evaluate the effectiveness of fucoidan gelatine containing chitosan injectable hydrogel in bone<br/>regeneration in rats by histopathological experimentation, a randomized laboratory experimental trial was<br/>conducted on 30 Albino Wistar rats. Animals were randomly distributed into 3 groups. Micro defects of<br/>2-3 mm were created in the tibia of each animal and the defects were treated with bone substitutes. Group 1<br/>was treated with 1 % fucoidan-0.5 % chitosan hydrogel, Group 2 served as control and Group 3 was filled<br/>with concentrated growth factor. All the animals were followed up for 28 d to appreciate wound healing<br/>and new bone formation. Fisher’s exact test was used to study the difference in bone regeneration and<br/>inflammation between the groups. The ratio of new bone per total area was significantly superior in both<br/>test groups when compared to the control group at the end of 28 d. New osteoblasts were significantly more<br/>in the fucoidan group followed by group 3 (p<0.05). No statistically significant difference in inflammation<br/>status was observed between the 3 groups (p>0.05) at both 14 and 28 d. The presence of fucoidan in the<br/>hydrogel significantly contributed to bone regeneration in animals thus proving to be a substitute for tissue<br/>engineering. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS