Li, Zhang <br/><br/>
Hydroalcoholic carthamus tinctorius l. Extract attenuates tnbs-induced ulcerative colitis in mice via downregulation of inflammation and oxidative stress 

 - Vol.56(3), Jul-Sep 
 - Karnataka  Association of Pharmaceutical Teachers of India (APTI)  2022 
 - 780-788p. 
<br/><br/> Background: Ulcerative colitis (UC) is distinct by severe inflammation of intestinal epithelial<br/>tissue and more than 2 million people worldwide are affected with ulcerative colitis.<br/>This disease is primarily driven by oxidative stress and inflammation. Objectives: To<br/>identify a safer remedy with less/no adverse effect, we investigated the beneficial ability<br/>of<br/>Carthamus tinctorius L. extracts to alleviate multi-factorial conditions like oxidative<br/>stress, lipid peroxidation, and inflammation in Trinitro benzenesulfonic acid induced<br/>experimental ulcerative colitis in mice. Materials and Methods: Ulcerative colitis in Balb/c<br/>mice were induced by intrarectal administration of TNBS. Hydroalcoholic<br/>Carthamus<br/>tinctorius L. extracts were supplemented orally and all mice were observed and scored<br/>for clinical manifestations. After sacrificing mice, inflammatory markers, colonic oxidative<br/>stress levels, and antioxidant enzymes were measured. Histological features of the colon<br/>were also analyzed. Results: Supplementing the TNBS-induced group with the plant<br/>extracts suppressed oxidative stress, enhanced cytoprotective antioxidants, and reduced<br/>inflammation. The histological evaluation also showed restoration of damaged tissues.<br/>Conclusion: Our findings indicate the curative ability of the hydroalcoholic<br/>Carthamus<br/>tinctorius L. extracts and can be a good therapeutic candidate to treat Ulcerative colitis.<br/>Keywords: Ulcerative colitis, TNBS,<br/>Carthamus tinctorius L., Oxidative stress,<br/>Inflammation. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS