Kala, Shabari Girinath  <br/><br/>
Synthesis, characterization and comparison of novel poly (sebacic anhydride) biopolymeric implants and microspheres for the controlled release of an anticancer drug 

 - Vol.56(2), Apr-June 
 - Karnataka  Association of Pharmaceutical Teachers of India (APTI)  2022 
 - 429-437p. 
<br/><br/> Aim: The purpose of this study was to investigate the comparative drug release kinetics<br/>of implants and microspheres of an anticancer drug loaded onto a bio-degradable polymer.<br/>Methods: Poly (sebacic anhydride) was synthesized using a melt-polycondensation<br/>reaction, and its physicochemical properties were determined using gel permeation<br/>chromatography, nuclear magnetic resonance, differential scanning calorimetry, and<br/>Fourier transform infrared techniques. The polymer was used to encapsulate drugs via<br/>the melt moulding technique for implants and the solvent evaporation technique for<br/>microspheres. Results:<br/>In-vitro degradation of implants showed a 95% degradation rate<br/>in 6 days with the disappearance of the anhydride peak due to polymer hydrolysis.<br/>The microspheres of size 63 ± 3 μm were found to be spherical and porous in optical<br/>microscopy images<br/>. In-vitro drug release from implants (85 ± 3.5%) and microspheres<br/>(88 ± 4.5%) in pH 7.4 revealed similar sustained drug release following Higuchi kinetics.<br/>Conclusion: There was no significant difference observed in drug release patterns from<br/>implants and microspheres with the same quantity of polymer. Therefore, poly (sebacic<br/>anhydride) could become a successful candidate for controlling the release of a drug over<br/>a long period of time. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS