Zhang, Yi-Heng <br/><br/>
Synthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection 

 - Vol.56(2), Apr-June 
 - Karnataka  Association of Pharmaceutical Teachers of India (APTI)  2022 
 - 573-579p. 
<br/><br/> It have been reported that the transition metal complex of Schiff base ligands have the<br/>ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes<br/>[Cd2<br/>(L)2·(H 2<br/>O)] (1), [Pb(L)·, [Pbe2<br/>) were synthesized based on chelating hydrazone<br/>ligand<br/>N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested<br/>by single crystal X-ray diffraction and determined by structure and tested for urease<br/>resistance<br/>in vitro. The complex 2 exhibited better the activities of inhibiting than the<br/>positive control acetohydroxamic acid with an IC50 =2.5<br/>μM, while the complex 1<br/>showed weak activity, and complex 2 acted as an effective urease inhibitor. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS