Madhuri A. <br/><br/>
Chemometric assisted spectrophotometric method development for evaluation of torsemide and eplerenone in their combined tablet dosage forms 

 - Vol.56(1), Jan-Mar 
 - Karnataka  Association of Pharmaceutical Teachers of India (APTI)  2022 
 - 253-263p. 
<br/><br/> Aim: In a present work two drugs Torsemide and Eplerenone were estimated from their<br/>combined tablet dosage forms by applying chemometric assisted spectrophotometric<br/>method. Methods: The methods are based on chemometrics a (multivariate) method<br/>which includes classical least square (CLS) and inverse least square (ILS). These methods<br/>were employed for simultaneous determination of Torsemide and Eplerenone in tablet<br/>dosage forms without any prior separation of components. For these methods the<br/>overlapping spectra of two drugs not subjected any conversions. The data processing of<br/>chemometric was accomplished by using software named Chemometrics Toolbox 3.02<br/>which is associated with MATLAB 6 and excel. Results: The results obtained from CLS<br/>and ILS methods were compared statistically. These chemometric methods were applied<br/>for the determination of these two drugs in their marketed tablet dosage form without<br/>any prior separation procedure of the drugs. The mean percent recoveries and values<br/>of relative standard deviation for these two methods were found to be 99.72/0.536<br/>for Torsemide and 100.06/0.384 for Eplerenone. Conclusion: The two chemometric<br/>methods developed can be successfully applied for the quantitative estimation of drugs<br/>from their dosage form. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS