Shaikh, T. K.  <br/><br/>
Development and validation of novel ultraviolet spectrophotometric method for estimation of antileishmanial drug buparvaquone 

 - Vol.84(1), Jan-Feb 
 - Mumbai  Indian Journal of Pharmaceutical Science  2022 
 - 130-136p. 
<br/><br/> A novel, simple, accurate, precise, economical and reliable ultraviolet spectrophotometric method has been<br/>developed for the estimation of buparvaquone in bulk and in pharmaceutical dosage form. The drug shows<br/>maximum absorption at 251 nm by using acetonitrile as solvent. The method was validated as stated in<br/>International Council for Harmonisation Q2 (R1) guidelines. It obeys Beer’s law in the concentration<br/>range of 2-20 μg/ml with correlation coefficient of 0.998. The drug shows great accuracy close to 100 %.<br/>The method was found to be robust and precise as the relative standard deviation are less than 2 %. Limit<br/>of detection and limit of quantitation were found to be 0.60 μg/ml and 1.83 μg/ml respectively. From the<br/>results of specificity, the drug was found to be more degraded under alkaline, oxidative and photolytic<br/>conditions. The proposed method can be employed for the reliable quantification of buparvaquone in bulk<br/>and routine analysis of pharmaceutical formulations. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS