Thanki, Pragna H. <br/><br/>
Synthesis, characterization and biological screening of various pharmacophoric derivatives of 4-alkylpyrimidine-5-carbonitrile 

 - Vol.61, Jan 
 - New Delhi  CSIR  2022 
 - 81-87p. 
<br/><br/> 4-Isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile has been used as a starting material. Reaction of 4-isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile with hydrazine hydrate and amine gives 2-hydrazino and 2-(alkyl/ substituted aryl amino)-4-isobutyl-1,6-dihydro-1-methyl-6-oxopyrimidine-5-carbonitrile compounds respectively. The hydrazino compounds react with different aromatic aldehydes, substituted benzene sulphonyl chloride and s-triazine derivative to form Schiff base, sulphonamide and s-triazine derivatives respectively. Reaction of Schiff base with mercapto lactic acid and chloroacetyl chloride yield 4-thiazolidinones and 2-azetidinones respectively. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>GENERAL CHEMISTRY