Synthesis and characterization of carbamates derivatives from 4-amino-1,2,4-triazole
- Vol.61(10), Oct
- New Delhi CSIR 2022
- 1113-1119p.
Carbamate derivatives are proved to be an essential class of molecules because of their application as drugs and prodrugs. Their several derivatives also have been used to craft the drug-target interfaces by incorporating the carbamate moiety. Due to the huge demand in pharma-industries these have been extensively explored and synthesized. The synthesis and characterization of carbamate derivatives from 4-amino-1,2,4-triazoles and 3-(methylthio)-4-amino-1,2,4-triazoles are described. Carbamate derivatives of 4-amino-1,2,4-triazoles with phenyl chloroformate in CH3CN using K2CO3 at ca. ~80°C have been synthesized with good to excellent yield (~81 to 97%). The methodology has been subsequently extended for synthesis of carbamate derivatives of 3-(methylthio)-4-amino-1,2,4-triazoles in which bicarbamate derivatives are formed as major products (~39 to 47%) along with mono carbamate derivatives as minor products (~9 to 22%) in the presence of similar solvent and base. On investigating the effect of solvent and base, the reaction in CH3CN in presence of K2CO3 shows the best results.