Jun, Li <br/><br/>
Recovery of diabetic ulcers facilitated by asiaticoside through activating the wnt/beta-catenin signalling cascade 

 - Vol.84(4), Jul-Aug 
 - Mumbai  Indian Journal of Pharmaceutical Science  2022 
 - 1006-1012p. 
<br/><br/> Diabetic ulcers, a type of chronic and refractory wound, are the most common diabetic complication<br/>and their incidence is increasing. However, the specific mechanisms underlying the formation of diabetic<br/>ulcers have not been clarified and the current therapeutic methods are unsatisfactory. In this study,<br/>we found that asiaticoside facilitated the recovery of skin wounds in diabetic rats. Intensive studies<br/>demonstrated that asiaticoside promoted fibroblast proliferation and migration in a high-glycemic<br/>environment. Mechanistically, asiaticoside upregulated Wnt1 at the protein and immunohistochemistry<br/>levels and activated the Wnt/beta-catenin signaling cascade, thereby promoting fibroblast functions. Thus,<br/>asiaticoside promotes skin cell activities relevant to diabetic ulcers healing and thus may have therapeutic<br/>value. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS