Exploring neuroprotective potential of cissus quadrangularis plant extract in parkinson’s disease
- Vol.17(3), Jul-Sep
- M P BRNSS Publication Hub. 2023
- 242-250p.
Background: Parkinson’s disease (PD) caused due to neuroinflammation and oxidative stress associated with motor and non-motor complications. Neuroprotection strategies create a hope for patients. Natural products have been increasing the gain to have specific molecular or pharmacological activities that are likely to supply the development of neuroprotective agents against PD. Cissus quadrangularis constitutes all suitable physical and chemical properties and its ability to cross the blood–brain barrier making it a relevant candidate for the treatment of neuroprotection in PD. Materials and Methods: The stem part of the plant was extracted with distilled water and ethanol. The antiparkinson’s activity of both extracts of C. quadrangularis was evaluated using rotenoneinduced excitotoxicity model in zebrafish for 96 h resulting in alterations in swimming pattern measured through a video recording system. Further, cognitive improvement activity in PD of both extracts of plant was evaluated using reserpine-induced cognitive impairments in mice for 29 days. Biochemical parameters, that is, levels of catalase and glutathione (GSH) were analyzed using UV-visible spectrophotometer. Results: The aqueous extract of C. quadrangularis (AECQ) showed a significant and dose-dependent effect against rotenone-induced PD in adult zebrafish’s at a dose of 4 and 10 ?g/mL and cognitive improvement activity against reserpine-induced cognitive impairment in mice at a dose of 200 mg/kg and 500 mg/kg. The AECQ also showed a significant in vivo antioxidant potential by restoring the levels of catalase and GSH. The results of the present study demonstrate the potential antiparkinson’s properties of the aqueous extract. Conclusion: The result of the present study conclusively shows the Anti-Parkinson’s activity of C. quadrangularis and improved cognition in PD.