Pawar, Shweta <br/><br/>
Formulation and evaluation of garlic powder loaded floating matrix tablet 

 - Vol. 2(3) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 17-21p. 
<br/><br/> Objective: <br/>The objective of the present work was to formulate and evaluate a stable, odour<br/> free garlic powder loaded floating matrix tablet for the <br/>treatment of peptic ulcers. <br/>Method<br/>s: <br/>A <br/>gastro<br/>-retentive <br/>floating  matrix  tablet  (FMT)  formulation  of  garlic  powder  (GP)  was  prepared  using  various  concentrations  of  <br/>hydroxypropyl <br/>methylcellulose<br/> K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable <br/>floati<br/>ng time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet. <br/>3<br/>2<br/>Result<br/>s: <br/>It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h <br/>with FT <br/>up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during <br/>the <br/>stability<br/> study of FMT.<br/> full factorial designs were used for selection of suitable polymer concentration and effervescent system. No<br/>nenteric film coating was applied to <br/>mask GP <br/>odour<br/>.<br/>Conclusio<br/>n: <br/>A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formu<br/>lation <br/>can overcome problems of taste and odour<br/> masking, gastric irritation, and loss of active constituents present in garlic. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS