Phenolic Constituents with Antioxidant and Antiviral Activities from Phyllanthus urinaria Linnea
- Vol. 81(3), May-June
- Mumbai Indian Journal of Pharmaceutical Science 2019
- 424-430p.
Phyllanthus urinaria Linnea is commonly used in folk medicine with considerable therapeutic utility. Sixteen phenols of Phyllanthus urinaria were isolated from ethanol extract and their structures were identifi ed by spectroscopic data. Oxygen radical absorbance capacity, radical scavenging assay and HBsAg and HBeAg ELISA kits were used to evaluate antioxidant and antiviral activities. All the isolates showed signifi cant antioxidant activity. Especially, isolates 4 and 5 had the oxygen radical absorbance capacity of 5.12 and 8.13 U/mol and strong radical scavenging activity with IC50 values of 5.50 and 5.55 μM, respectively. Additionally, these studies also demonstrated that the compounds 1, 2, 11, 12, and 16 inhibited secretion of HBsAg and HBeAg in HepG2.2.15 cells. This study suggested that the phenolic constituents of Phyllanthus urinaria possessed antioxidant activities and these might play an important role in antihepatitic effects.