Dey, Soumen <br/><br/>
Concise formal synthesis of (-)-(6R,11R,14R)-colletallol via D-proline catalysed α-aminooxylation-Wittig olefination strategy  

 - Vol.58B(9), Sep 
 - New Delhi  CSIR  2019 
 - 1029-1036p. 
<br/><br/> An  efficient  enantioselective  formal  synthesis  of  marine  macrolide  (−)-(6R,11R,14R)-colletallol  has  been  achieved starting from commercially available raw materials. The key reactions include the D-proline catalyzed α-aminooxylation of aldehyde   followed   by  Horner-Wardsworth-Emmons   olefination   in  a   sequential   fashion   to   give   the   macrolide   key intermediate 5 in high enantiomeric purity (97% ee) and high overall yield (32%). 
<br/><br/><label>Subjects--Topical Terms: </label><br/>GENERAL CHEMISTRY