Arirudran, B. <br/><br/>
EVALUATION OF ANTIOXIDANT AND CHEMOPREVE NTIVE POTENTIAL OF M ETHANOLIC  EXTRACTS OF LEAF OF  AEGLE MARMELOS  ATTRIBUTES TOWARDS DUCTAL  CARCINOMA  STUDIED IN MCF7  CELLS  

 - Vol.11(2) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 21-25p. 
<br/><br/> Objective<br/>: <br/>The  objective  of  the  present  research  work<br/>  ha<br/>d  been  made  to  evaluate  the  a<br/>ntioxidant  potential  along  with  anti<br/>-cancer <br/>activity<br/>  of <br/>methanolic extracts<br/> from <br/>the <br/>leaf<br/> of <br/>A. marmelos<br/>.  <br/>Method<br/>s: <br/>Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and <br/>anticancer <br/>activity<br/> in vitro<br/> method <br/>(Cytotoxicity<br/>/MTT assay<br/> and % of cell viability<br/>) by using<br/> MCF7 cell line.<br/>Result<br/>s: <br/>Results of antioxidant efficacy reveal<br/>ed that the IC<br/>50<br/> value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and <br/>20.69%  respectively.  The  methanolic  extract  of  <br/>A<br/>.  marmelos<br/>  was  found  to  possess  <br/>enhanced<br/>  anticancer<br/>  potential  against  MCF7  cells.  Cytotoxicity  <br/>activity  of  MCF7  cells<br/>,  when  treated  with  methanolic<br/>  extract  of  A.  marmelos<br/>,  was  found  to  be  43.42%  at  25μg<br/>,  52.31%  at  50μg,<br/>  56.31%  at  75μg,<br/>58.38%  at  100μg<br/>,  62.25%  at  125μg.  The  IC<br/>50<br/>Conclusio<br/>n: <br/>From  the  <br/>studies<br/>,  it  was  postulated  that  methanolic  extract  of  leaf  from  <br/>A.  marmelos<br/>has<br/>  significant  chemopreventive  activity.  These  <br/>specific identities will be useful for the identification and authentication of raw<br/> drug. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS