Sharma, Saruchi <br/><br/>
ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR  IN-SITU  RELEASE OF  PANTOPRAZOLE SODIUM  

 - Vol.11(4) 
 - M P  Innovare Academic Sciences Pvt Ltd  2019 
 - 98-103p. 
<br/><br/> Objective: <br/>This study involves the synthesis of <br/>Gum tragacanth <br/>(gt) based interpenetrating polymer network (ipn) a<br/>nd its utilization for sustained <br/>release of anti-ulcerative drug i.e. pantoprazole s<br/>odium. <br/>Methods: <br/>IPN was synthesized from Gum tragacanth, polyacryli<br/>c acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in <br/>distilled water. Further, acryamide <br/>(aam) and methylmethacrylate (mma) was added and th<br/>en kept for overnight. Later on, lipase and glutara<br/>ldehyde were added. Homopolymers and <br/>the unreacted monomers were removed using acetone. <br/>Synthesized IPN was dried at 50 °C for further stud<br/>y. <br/>Synthesized ipn was swelled in water and the drug w<br/>as added to it. The drug was entrapped in the pores<br/> of the synthesized ipn and then drug <br/>release behavior was studied using uv-vis spectroph<br/>otometer.  <br/>Results: <br/>Gt, <br/>paa and mma based crosslinked IPN were synthesized <br/>using lipase-glutaraldehyde as initiator-crosslinke<br/>r system. The synthesized IPN <br/>was pH sensitive and possessed the desired swelling <br/>capacity required for the controlled and systematic<br/> liberation of pantoprazole sodium at 37 °C. <br/>The kinetic of drug release was studied and found t<br/>hat lateral diffusion (D<br/>L<br/>) of drug was higher as compared to the initial dif<br/>fusion (D<br/>I<br/>). The <br/>prepared IPN can be used as prospective carrier for<br/> prolonged drug delivery.  <br/>Conclusion: <br/>A  novel  pH  sensitive  and  colon  targeted  IPN  was  synt<br/>hesized.  It  acts  as  an  effective  device  for  the  con<br/>trolled  release  of  drug <br/>pantoprazole sodium.  
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS