NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST CISPLATIN INDUCED NEPH ROTOXICITY IN EXPERIMENTAL RATS
- Vol.11(4)
- M P Innovare Academic Sciences Pvt Ltd 2019
- 108-113p.
Objective: The current study was designed to evaluate the pro tective effect of standardized hydroalcoholic extra ct of Plumeria rubra (HAEPR) against cisplatin-induced nephrotoxicity in Wistar rats. Methods: HAEPR was administered orally at 3 dose levels (100 ,200,400 mg/kg). Vitamin E (250 mg/kg) was used as a Standard nephroprotective agent. The kidney function test (estimation of seru m creatinine, albumin, blood urea nitrogen) oxidati ve stress study (estimation of superoxide dismutase, malondialdehyde activity) and histologic al examination of kidneys was conducted. Results: The efficacy of HAEPR was compared with Cisplatin ( CP) treated group. Serum creatinine and BUN was sig nificantly (p<0.01) elevated in CP-treated group compared to the control group. HAE PR (100,200 mg/kg) and Vitamin E (250 mg/kg) signif icantly (p<0.01) decreased the serum creatinine and BUN levels. CP treated group exhibit ed significant (p<0.01) decrease in albumin when co mpared to control. Significant (p<0.01) increase in the serum albumin level was found in HAE PR (100,200 mg/kg) and Vitamin E (250 mg/kg) compar ed to CP group. Significant (p<0.01) decrease in the activity of SOD was observed in the CP group as compared to control. HAEPR (100 and 20 0 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) increased SOD levels. HAEPR ( 400 mg/kg) significantly (p<0.05) increased SOD lev els. HAEPR (100,200,400 mg/kg) significantly (p<0.01) decreased MDA levels as comp ared to CP group. Histopathological examination of t he kidneys showed that HAEPR markedly ameliorated Cisplatin-induced renal tubular necrosi s. An extract was found effective at all doses, alt hough low dose (100 mg/kg) was found to be more effective and comparable with the standard gro up (Vitamin E 250 mg/kg).