Yasmin Begum, M. <br/><br/>
FORMULATION AND EVALUATION OF DASATINIB LOADED SOLID LIPID  NANOPARTICLES 

 - Vol.10(12) 
 - M P  Innovare Academic Sciences Pvt Ltd  2018 
 - 14-20p. 
<br/><br/> Objective: <br/>Method<br/>s: <br/>SLNs consist of a solid lipid matrix<br/> where  the  drug  <br/>was<br/> incorporated<br/>. Surfactants of GRAS grade were used t<br/>o avoid aggregation and to <br/>stabilize  the  SLNs. <br/>DST<br/>-SLN<br/>s  formulations  of  varying  con<br/>centrations  were  prepared  by  high<br/>-speed<br/>  homogenization  technique  and  evaluated  for  <br/>drug excipients compatibility study, poly<br/>-dispersity index, particle size analysis, surface <br/>morphology, zeta potential<br/>, and<br/> drug release features. <br/>The aim of present work wa<br/>s to formulate and <br/>evaluate <br/>Dasatinib<br/> (DST) <br/>loaded solid lipid nanoparticles<br/> (SLNs) <br/>as a potential antic<br/>ancer <br/>drug delivery system<br/> by enhancing its solubility.<br/>Result<br/>s: <br/>It  was  observed  that <br/>DST<br/>-SLNs  with  optimum<br/>  quantities  o<br/>f   poloxome<br/>r:  lecithin  ratio  showed  88.06%  drug  release<br/>  in  6h<br/>  with  good  <br/>entrapment  efficiency  of  76.9±0.84  %<br/>.  Particle  size,  Polydispersity<br/>  index,  zeta  potential  and  drug  entrapment  efficiency  for  the  optimized  <br/>formula<br/>tion was found to be<br/> optimum<br/>. Stability studies <br/>revealed that the entrapment efficiency of the SLN dispersion stored in 4<br/> °C was stable.<br/>Conclusio<br/>n<br/>:<br/>Thus,  it  can  be  concluded  that  <br/>the <br/>formulations<br/> of <br/>DST  loaded  SLNs<br/> are  suitable  carriers  for  improving  the  <br/>solubility  and  dissolution  <br/>related problems. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS