Akhila, C. <br/><br/>
In vitro DNA binding studies of selected heterocyclic compounds  

 - Vol. 55(12), December 
 - Mumbai  Indian Drug Manufacture's Association - IDMA  2018 
 - 24-26 
<br/><br/> DNA binding studies of selected heterocyclic compounds belonging to the class of quinolinones, substituted quinolinones and thiones were carried out using ct-DNA. The binding nature of the compounds with DNA analyzed using UV-spectroscopy revealed the compounds to be DNA intercalators demonstrating the binding nature of compounds with DNA base pairs. This study is aimed at establishing a facile UV spectroscopic technique to arrive at the binding mode of DNA to ligands. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICS