Oral diuretic activity of hot water extract of H-grade quills of chnnamomum zeylanicum blume in rats
By: Jayaweera, Gihani
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Contributor(s): Makuloluwa, Thamasi | Perera, Kamal.
Publisher: M. P. Innovare Academic Sciences Pvt Ltd 2018Edition: Vol. 10(10), July-August.Description: 114-118.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective: Cinnamomum zeylanicum Blume is claimed in Sri Lankan traditional medicine as a diuretic. Diuretics that are in current use possess serious adverse effects. Thus, there is a need for discovering efficacious and safe diuretics possibly from natural sources. Hence, the study was carried out to scientifically evaluate the diuretic potential of Cinnamomum zeylanicum Blume in vivo. Methods: Wistar albino rats weighing 180-270 g of either sex were divided into five groups containing six subjects in each. All were starved for 18 h and hydrated subsequently with oral sodium chloride solution (0.9%). Group, I (control) received normal saline (15 ml per animal orally). Group II, III, and IV received different doses (1500, 2250, 3000 mg/kg) of freeze-dried hot water extract of Cinnamomum zeylanicum Blume orally. Group V; (standard) received furosemide (13 mg/kg). Rats were placed individually in metabolic cages. Cumulative urine outputs at hourly intervals for six hours, urinary Na+, K+, Cl-, HCO3-Results: A strong dose-dependent diuretic activity with a rapid onset of action, rapid peak diuresis and short duration of action was observed compared to furosemide. The diuretic action was accompanied with a significant (p<0.05) increase in urinary Na, specific gravity, pH and total dissolved solids were determined. +, HCO3- and pH and decrease in urinary H+Conclusion: The results indicated that hot water extract of Cinnamomum zeylanicum Blume possesses marked diuretic action compar....
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School of Pharmacy Archieval Section | Not for loan | 2018428 |
Objective: Cinnamomum zeylanicum Blume is claimed in Sri Lankan traditional medicine as a diuretic. Diuretics that are in current use possess serious adverse effects. Thus, there is a need for discovering efficacious and safe diuretics possibly from natural sources. Hence, the study was carried out to scientifically evaluate the diuretic potential of Cinnamomum zeylanicum Blume in vivo. Methods: Wistar albino rats weighing 180-270 g of either sex were divided into five groups containing six subjects in each. All were starved for 18 h and hydrated subsequently with oral sodium chloride solution (0.9%). Group, I (control) received normal saline (15 ml per animal orally). Group II, III, and IV received different doses (1500, 2250, 3000 mg/kg) of freeze-dried hot water extract of Cinnamomum zeylanicum Blume orally. Group V; (standard) received furosemide (13 mg/kg). Rats were placed individually in metabolic cages. Cumulative urine outputs at hourly intervals for six hours, urinary Na+, K+, Cl-, HCO3-Results: A strong dose-dependent diuretic activity with a rapid onset of action, rapid peak diuresis and short duration of action was observed compared to furosemide. The diuretic action was accompanied with a significant (p<0.05) increase in urinary Na, specific gravity, pH and total dissolved solids were determined. +, HCO3- and pH and decrease in urinary H+Conclusion: The results indicated that hot water extract of Cinnamomum zeylanicum Blume possesses marked diuretic action compar....
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