Preparation and evaluation of O/W and W/O microemulsions containing diclofenac sodium
By: Yang, Hui
.
Contributor(s): Amnuaikit, Thanaporn.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(1), Jan-Feb.Description: 84-92p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Microemulsions are widely used as potential drug delivery systems, especially through the dermal route
as a means to avoid systemic side effects. Also, it is well known that the formation and characteristics of
microemulsions depend on their composition. This study aimed to investigate the influence of various types
and ratios of components which could dissolve diclofenac sodium on microemulsion formation in term of
size of microemulsion regions through the construction of sixteen pseudoternary phase diagrams using the
titration method. The data obtained were used to prepare oil-in-water and water-in-oil diclofenac sodium
microemulsions. Two o/w and two w/o blank microemulsions were selected from the system providing the largest
microemulsion region and these were subsequently incorporated with 1 % w/w diclofenac sodium. Afterward,
their physicochemical and drug release properties were assessed. The largest microemulsion region was found
in the system consisting of 2:1 Cremophor RH40:Span 80, ethylhexyl palmitate and 2:1 water:isopropanol.
Characteristics of diclofenac sodium microemulsions were similar to those of their blank counterparts, with
the exception of the drug-contained microemulsions having higher conductivity. Our findings indicated
that compatibility of oil and surfactant structures was the crucial parameter for microemulsion formation.
Furthermore, the present research not only expanded the phase behavior studies of microemulsions using
different blends of Cremophor RH 40 and Span 80 as surfactant and cosurfactant mixtures, but also reported
the application of ethylhexyl palmitate in microemulsion formulations. Incorporation of diclofenac sodium
into four studied microemulsions did not affect microemulsion type. Location of the drug, drug mobility and
interfacial film rigidity in microemulsions were found to influence the release characteristics of the loaded
drug.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022628 |
Microemulsions are widely used as potential drug delivery systems, especially through the dermal route
as a means to avoid systemic side effects. Also, it is well known that the formation and characteristics of
microemulsions depend on their composition. This study aimed to investigate the influence of various types
and ratios of components which could dissolve diclofenac sodium on microemulsion formation in term of
size of microemulsion regions through the construction of sixteen pseudoternary phase diagrams using the
titration method. The data obtained were used to prepare oil-in-water and water-in-oil diclofenac sodium
microemulsions. Two o/w and two w/o blank microemulsions were selected from the system providing the largest
microemulsion region and these were subsequently incorporated with 1 % w/w diclofenac sodium. Afterward,
their physicochemical and drug release properties were assessed. The largest microemulsion region was found
in the system consisting of 2:1 Cremophor RH40:Span 80, ethylhexyl palmitate and 2:1 water:isopropanol.
Characteristics of diclofenac sodium microemulsions were similar to those of their blank counterparts, with
the exception of the drug-contained microemulsions having higher conductivity. Our findings indicated
that compatibility of oil and surfactant structures was the crucial parameter for microemulsion formation.
Furthermore, the present research not only expanded the phase behavior studies of microemulsions using
different blends of Cremophor RH 40 and Span 80 as surfactant and cosurfactant mixtures, but also reported
the application of ethylhexyl palmitate in microemulsion formulations. Incorporation of diclofenac sodium
into four studied microemulsions did not affect microemulsion type. Location of the drug, drug mobility and
interfacial film rigidity in microemulsions were found to influence the release characteristics of the loaded
drug.
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