000			a
999			_c10380 _d10380
003			OSt
005			20191202161323.0
008			191202b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_910906 _aSasidharan, Maneesha
245			_aIncidence and Predictors of Contrast-induced Nephropathy in Patients Undergoing Percutaneous Coronary Interventions at an Indian Tertiary Care Center
250			_aVol. 81 (04)
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a729-736p.
520			_aThis investigation is aimed to assess the incidence and possible risk factors of contrast-induced nephropathy and also the utility of Mehran risk score for prediction of contrast-induced nephropathy in patients undergoing percutaneous coronary interventions. A cross-sectional observational study was conducted on 480 patients who underwent percutaneous coronary interventions. Patients with and without contrast-induced nephropathy were evaluated to recognize the predictive factors of contrast-induced nephropathy and explored the benefit of Mehran’s risk score for prediction of contrast-induced nephropathy using receiver operating characteristics curve, Youden’s index and a likelihood ratio test. The incidence of contrast-induced nephropathy was 5.2 % (95 % confidence interval- 4.75¬ to 5.65). The associated risk factors were diabetes mellitus, hypertension, age >75 years and contrast volume ≥100 ml (p>0.001). Multivariate analysis identified age >75 years and hypertension as independent risk factors. Low Mehran risk category (score <5) patients had a higher occurrence (56 %) of contrast-induced nephropathy compared to other Mehran risk groups. Mehran risk scoring had high sensitivity (63.1 %) and low specificity (44 %) which was affirmed by Youden’s index (0.071) and an area under the receiver operating characteristics curve of 0.592. Contrast-induced nephropathy is a possible risk factor for all patients undergoing percutaneous coronary interventions. Contrast volume ≥100 ml, age >75 years, diabetes mellitus and hypertension were the predictors of contrast-induced nephropathy. Mehran risk score appeared irrelevant in stratifying the risk of contrast-induced nephropathy in patients undergoing percutaneous coronary interventions.
650		0	_94639 _aPHARMACEUTICS
700			_910908 _aJames, E.
773	0		_tIndian journal of pharmaceutical sciences _dNew Delhi Indian Pharmaceutical Association _x0250-474X
856			_uhttp://www.ijpsonline.com/articles/incidence-and-predictors-of-contrastinduced-nephropathy-in-patients-undergoing-percutaneous-coronary-interventions-at-an-indian-te-3674.html _yClick here
942			_2ddc _cAR