000			a
999			_c10493 _d10493
003			OSt
005			20191209161908.0
008			191209b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_911065 _aShinde, S. V.
245			_aLipid nanoparticles for transdermal delivery of clecoxib: An in vito and in vivo investigation
250			_aVol. 56 (08)
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2019
300			_a38-48p.
520			_aIn the present research work, celecoxib (CXB) loaded solid lipid nanoparticles (SLNs) were prepared using the probe sonication method, wherein Glyceryl monostearate and Tween 80 were used as solid lipid and surfactant, respectively. To obtain the statistically optimized batch, 32 factorial design was applied. The optimized batch was characterized physicochemically and evaluated through DSC, SEM and XRD studies. The mean particle size of the optimized batch was found to be 135.41± 0.24 nm with a mean % entrapment efficiency of 80 ± 1.69%. The optimized batch was further lyophilized and dispersed into 1% w/v Carbopol 934P to form a gel. Prepared gel was further evaluated for in vitro drug release, occlusivity, ex vivo permeability, local toxicity, in vivo anti-inflammatory activity and accelerated stability study. The study resulted in stable, safe and prolonged anti-inflammatory activity with quick onset of action. Hence, celecoxib loaded solid lipid nanoparticles can be considered as promising alternative to conventional topical systems.
650		0	_94639 _aPHARMACEUTICS
700			_911103 _aNikam, S.
773	0		_tIndian drugs _dMumbai Indian Drug Manufactures Association
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=OTYz _yClick here
942			_2ddc _cAR