000			a
999			_c10651 _d10651
003			OSt
005			20191221120218.0
008			191221b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_911337 _aTascon-otero, Estefania
245			_aEnhancement of the Dissolution Rate of Indomethacin by Solid Dispersions in Low-substituted Hydroxypropyl Cellulose
250			_aVol. 81 (05)
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a824-833p.
520			_aIn the present study, new indomethacin formulations were developed in order to enhance the indomethacin dissolution rate by preparing solid dispersions using the freeze-drying method. The degree of alterations in the crystallinity of indomethacin was assessed according to the preparation method and by the addition of low-substituted hydroxypropyl cellulose. Solid dispersions improved the dissolution rate of indomethacin. Combined use of scanning electron microscopy, X-ray powder diffraction and differential scanning calorimetry revealed the basis of the increase in dissolution rate of indomethacin when formulated as low-substituted hydroxypropyl cellulose solid dispersions.
650		0	_94639 _aPHARMACEUTICS
700			_911338 _aTorre-Iglesias, Paloma
773	0		_tIndian journal of pharmaceutical sciences _x0250-474X _dNew Delhi Indian Pharmaceutical Association
856			_uhttp://www.ijpsonline.com/articles/enhancement-of-the-dissolution-rate-of-indomethacin-by-solid-dispersions-in-lowsubstituted-hydroxypropyl-cellulose-3696.html _yClick here
942			_2ddc _cAR