000			a
999			_c10880 _d10880
003			OSt
005			20200110122257.0
008			200110b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_911645 _aKarale, S.
245			_aAnti-inflammatory and antinociceptive activities of gymnemic acid in wistar rats
250			_aVol.56(2), Feb
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2019
300			_a57-63p.
520			_aThe present study was aimed to evaluate anti-inflammatory and antinociceptive activities of gymnemic acid (GA) in Wistar rats. The different doses of GA were tested for their anti-inflammatory in carrageenaninduced rat paw oedema animal model by using buzzer assisted plethysmograph and antinociceptive activities by tail immersion screening model in organ bath, respectively. It was found that GA at the dose of 100 and 150 mg/kg, p.o, significantly (P<0.01) inhibited the carrageenan-induced rat paw edema and significantly (P<0.01) suppressed the threshold pain of rat by tail immersion method. GA showed significant anti-inflammatory and antinociceptive activities at 2nd and 3rd hr. Further, to know the possible mode of action, we evaluated the effect of GA on castor oil-induced diarrhea. The frequency of stool formation was reduced due to GA in castor oil-induced diarrhea, perhaps due to suppression of prostaglandin, suggesting anti-inflammatory and antinociceptive activities. The current findings demonstrate that the administration of GA at the dose of 100 and 150 mg/kg, by oral route produced significant anti-inflammatory and antinociceptive effects in Wistar rats.
650		0	_94639 _aPHARMACEUTICS
700			_911646 _aKulkarni, V. H.
773	0		_dMumbai Indian Drug Manufactures Association _tIndian drugs
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=ODk5 _yClick here
942			_2ddc _cAR