000			a
999			_c10888 _d10888
003			OSt
005			20200113114355.0
008			200113b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_911658 _aNavale, Govind
245			_aMembrane Stabilization assay for Anti-inflammatory activity yields misleading results for samples containing traces of Methanol
250			_aVol.9(3), Jul-Sep
260			_aRaipur _bAsian Pharma Press _c2019
300			_a169-171p.
520			_aThere is an increased in the reports on erythrocyte haemolysis assay being used as a simple and rapid tool for screening of drugs and phytochemicals for anti-inflammatory activity. However, in case of hydroalchoholic extracts, there is a possibility of the trace amounts of methanol retained even after drying. These traces are not acconted in the assay units. The present study was designated to substantiate the effects of low concentrations of methanol on the heat induced haemolysis. It was observed that the presence of methanol at concentrations as low as 0.1 ?l/ml exert significant membrane stabilizing activity. Thus, this assay may give misleading results if the test drug solution contains even slighest amount of methanol. Therefore, Present study suggested that the heat-induced erythrocyte haemolysis assay is not suitable for testing membrane stabilizing and anti-inflammmatory activity of the test samples containing methanol.
650		0	_94639 _aPHARMACEUTICS
700			_911659 _aPatil, Dipak D.
773	0		_tAsian journal of pharmaceutical research _x2231-5683 _dRaipur Asian Pharma Press
856			_uhttps://asianjpr.com/AbstractView.aspx?PID=2019-9-3-5 _yClick here
942			_2ddc _cAR