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| 999 |
_c11056 _d11056 |
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| 003 | OSt | ||
| 005 | 20200124145202.0 | ||
| 008 | 200124b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_911926 _aSakina Fatima |
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| 245 | _aIncidence of multidrug resistance and extended‑spectrum beta‑lactamase expression in community‑acquired urinary tract infection among different age groups of patients | ||
| 250 | _aVol.50(2), Mar-Apr | ||
| 260 |
_aMumbai _bWolter Kluwer _c2019 |
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| 300 | _a69-74p. | ||
| 520 | _aOBJECTIVES: Urinary tract infection (UTI) is a frequent disorder and depends on age and gender. Ineffective empiric treatment of UTI is common when associated with extended‑spectrum beta‑lactamase (ESBL)‑producing Escherichiacoli and Klebsiellapneumoniae. The aim of the study was to investigate the prevalence of Gram‑negative uropathogens of E. coli and K.pneumoniae in different age groups along with the identification of ESBL‑producing uropathogens and antimicrobialsusceptibility profiles.MATERIALS AND METHODS: Atotal of 247 uropathogens of E. coli and K.pneumoniae were collected over a period of 1 year (January–December 2015) from various diagnostic centers of Karachi city (Pakistan). Antimicrobial susceptibility analysis was performed by disc diffusion method, and identification of ESBL was performed by double disc synergy test. Categorical data of ESBL and non‑ESBL uropathogens were analyzed by Pearson’s Chi‑square test.RESULTS: The study of 247 patients with community‑acquired UTI comprised 72% females and 28% males, illustrating an increased prevalence of UTIs among females. It was also revealed that 90% belonged to the age group of 16–30 years whereas 78% related to the age group of 46–60 years. ESBL was found positive in 33.5% (63/188) of E. coli and 15.25% (9/59) in K. pneumonia, with a significant association i.e., (p=0.007). Amikacin, fosfomycin, imipenem, and tazobactam/piperacillin were found to be the effective treatment options. A significant association was found between ESBL‑producing uropathogens against ciprofloxacin, enoxacin, and amoxicillin/clavulanic acid resistance (P < 0.05).CONCLUSIONS: It was concluded that for effective treatment of UTIs, appropriate screening of ESBL and culture sensitivity must be employed instead of empiric treatment. | ||
| 650 | 0 |
_94774 _aPHARMACOLOGY |
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| 700 |
_911927 _aIyad, Neeam |
||
| 773 | 0 |
_tIndian Journal of Pharmacology _dAndheri - Mumbai Wolters Kluwer India Private Limited _x0253-7613 |
|
| 856 |
_uhttp://www.ijp-online.com/temp/IndianJPharmacol50269-333931_091633.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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