000			a
999			_c11119 _d11119
003			OSt
005			20200207155647.0
008			200207b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912017 _aPatel, Pinak
245			_aQUANTITATIVE ANALYSIS OF PAMABROM AND IBUPROFEN IN SYNTHETIC MIXTURE USING 1 ST ORDER DERIVATIVE SPECTROSCOPY
250			_aVol.11(10)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2019
300			_a26-32p.
520			_aObjective: The preliminary goal was to develop and validate 1 st order derivative spectroscopic method for quantita tive analysis of Pamabrom (PAMA) which is a xanthine diuretic and ibuprofen ( IBU) which is a non-steroidal anti-inflammatory age nt from its synthetic mixture. Methods: Analytical method was developed on Shimadzu double beam spectrophotometer equipped with UV probe 2.42 as software using methanol as solvent. Quantification of PAMA was car ried out at zero cross over point of IBU that is 29 1 nm and for IBU, it was achieved at 278 nm which is zero cross over point of PAMA. Method was validated according to ICH Q2 R1 guidelines. Results: Method showed a linear response in the range of 2-1 2 μg/ml of PAMA and 20-120 μg/ml of IBU. Method was found to be accurate with recovery between 99.7–100.9 % for PAMA and 100.3–100.7 % for IBU. The method was found to be accurate and preci se for quantitative analysis of PAMA and IBU. Conclusion: The developed method was successfully validated as per ICH Q2 R1 guidelines and was successfully appli ed for quantitative analysis of a synthetic mixture of PAMA and IBU.
650		0	_94639 _aPHARMACEUTICS
700			_912018 _aVasani, Priyanka
773	0		_x2656-0097 _tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/34797/20904 _yClick here
942			_2ddc _cAR