000			a
999			_c11196 _d11196
003			OSt
005			20200212135250.0
008			200212b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912152 _aRajesh, R.
245			_aVALIDATED RP -HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PYRANTEL PAMOATE AND PRAZIQUANTEL IN BULK AND PHARMACEUTICAL DOSAGE FORM
250			_aVol.1(5)
260			_aM P _bInnovare Academic Sciences Pvt Ltd _c2019
300			_a62-67p.
520			_aObjective: To develop a simple, accurate and precise reverse- phase high -performance liquid chromatography ( RP -HPLC ) metho d and subsequently validate for the simultaneous estimation of praziquantel (PZ Q) and pyrantel pamoate (PP) in the pharmaceutical dosage form. Method s: The chromatographic separation was achieved on Phenomenex Luna C 18 Result s: The retention time of PZQ and PP was found to be 3.897 min and 1.697 min re spectively. The method was validated in terms of specificity, accuracy, precision, linearity and robustness as per ICH guidelines. Linearity was obtained in the concentration range of 20 – 60 μg /ml for both PZQ and PP with correlation coefficients of 0.987 and 0.998 respectively. The accuracy of the method was determined using a recov ery test and found as 98.44 % to 100.35 %. All parameters are found to be within the acceptable limit. column (250 mm × 4.6 mm, 5 μm) as st ationary phase maintained at an ambient temperature with a mobile phase comprising of wate r: acetonitrile (20 : 80) at a flow rate of 1.0 ml/min and UV detection at 220 nm. Conclu sio n: The developed RP -HPLC method was simple, rapid, accurate, precise for the simultaneous estimation of PZQ and PP in bulk and tablet dosage form
650		0	_94639 _aPHARMACEUTICS
700			_912153 _aJames,Jithu Jerin
773	0		_dBhopal Innovare Academic Sciences Pvt Ltd _tInternational journal of pharmacy and pharmaceutical science _x2656-0097
856			_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/30488/19866 _yClick here
942			_2ddc _cAR