000 a
999 _c11213
_d11213
003 OSt
005 20200213120636.0
008 200213b xxu||||| |||| 00| 0 eng d
040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _912184
_aAnitha, K.
245 _aANTIHYPERLIPIDEMIC EFFECT OF ETHANOLIC SEED EXTRACT OF CANAVALIA ENSIFORMIS ( L) IN HIGH FAT DIET -STREPTOZOTOCIN INDUCED RATS
250 _aVol.11(1)
260 _aM P
_bInnovare Academic Sciences Pvt Ltd
_c2019
300 _a99-102p.
520 _aObjective: It was investigated to enlighten the phytochemical screening and antihyperlipidemic activity of seeds of Canavalia ensiformis (L.) in High fat diet Streptozotocin -induced diabetic rats. Method s: The e thanolic seed extract of Canavalia ensiformis (EECE) at a dose of 40 0 mg /kg and 200 mg/kg was administered to diabetic r ats. Simvastatin ( 4 mg/kg) is used as a standard drug. Result s: The statistics were assessed by using one way ANOVA followed by Dunnet’s multiple comparison tests. To unfold the mechanism we studied all the biochemical parameters like Total cholesterol (T C), Triglycerides (TG), high -density lipoproteins (HDL ), low -density lipoproteins (LDL ) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of Canavalia ensiformis showed significant reduce of the level of cholesterol , triglycerides, LDL, VLDL and a significant increase in the serum level of HDL at 40 0 mg /kg rather than 200 mg/kg. Conclusio n: Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic ac tiv ity. Statistical analysis of this screening method conforms that the proposed method is appropriate and it can be useful, gives the basic idea to the researcher who is working in an area like Antihyperlipidemic activity.
650 0 _94639
_aPHARMACEUTICS
700 _912185
_aPuthalapattu, Ravikumar Yashoda
773 0 _dBhopal Innovare Academic Sciences Pvt Ltd
_x2656-0097
_tInternational journal of pharmacy and pharmaceutical science
856 _uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/28961/16555
_yClick here
942 _2ddc
_cAR