| 000 | a | ||
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| 999 |
_c11264 _d11264 |
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| 003 | OSt | ||
| 005 | 20200214115236.0 | ||
| 008 | 200214b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_912272 _aNikam, D. A. |
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| 245 | _aSYNTHESIS AND EVALUATION OF NOVEL CHEMICAL ENTITIES AS ANTI-BREAST CANCER AGENTS | ||
| 250 | _aVol.56(12), Dec | ||
| 260 |
_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2019 |
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| 300 | _a28-31p. | ||
| 520 | _aA series of dihydropyrimidone derivatives was synthesized by an efficient, simple and solvent less green method by using Beginelli reaction. Various aromatic aldehydes, urea and ethyl acetoacetate were refluxed for a few hours and the reaction monitored by periodic TLC (hexane: ethyl acetate 6:4 v/v) and products are purified by recrystallization, with characterization by FTIR, 1H NMR. All the purified compounds were subjected to evaluatation by in vitro human breast cancer cell line MDA-MB-231 and MCF-7. Compound I-k was found to be moderately active against MCF-7 with GI 50 value of -4.38. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_912273 _aTanvar, S. |
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| 773 | 0 |
_dMumbai Indian Drug Manufactures Association _tIndian drugs |
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| 856 |
_uhttp://www.indiandrugsonline.org/issuesarticle-details?id=MTAwMg== _yClick here |
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| 942 |
_2ddc _cAR |
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