000			a
999			_c11271 _d11271
003			OSt
005			20200214144809.0
008			200214b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912283 _aDhokchawle, B. V.
245			_aSYNTHESIS AND EVALUATION OF NAPROXEN ESTER PRODRUGS
250			_aVol.56(01), Jan
260			_aMumbai _bIndian Drug Manufacture's Association - IDMA _c2019
300			_a25-31p.
520			_aThe present works deals with simple and efficient method of improving therapeutic efficacy of naproxen by retarding gastrointestinal side effects through masking of carboxylic group chemically. This is achieved by synthesis of ester prodrugs of naproxen with various naturally available antioxidants; menthol, thymol, eugenol, guiacol, vanillin and sesamol by the dicyclohexyl carbodiimide (DCC) coupling method. The title compounds are purified and characterized by spectral data. Further, their partition coefficients have been determined and hydrolytic studies have been performed. The synthesized compounds are more lipophilic compared to the parent moieties and are stable in acidic environment, which is a prerequisite for their oral absorption. Under gastric as well as intestinal pH conditions, these prodrugs showed variable susceptibility towards hydrolysis. The title compounds when evaluated for anti-inflammatory and analgesic activities showed improvement over the parent drug. Prodrugs were also found to be significantly less ulcerogenic then parent drugs.
650		0	_94639 _aPHARMACEUTICS
700			_912284 _aAsirvatham, S.
773	0		_tIndian drugs _dMumbai Indian Drug Manufactures Association
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=ODg0 _yClick here
942			_2ddc _cAR