000			a
999			_c11285 _d11285
003			OSt
005			20200215100310.0
008			200215b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912306 _aPushpa Kumari, K.
245			_aSTABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF EMTRICITABINE, BICTEGRAVIR AND TENOFOVIR ALAFeNAMIDE
250			_aVol.57(01), Jan
260			_aMum bai _bIndian Drug Manufacture's Association - IDMA _c2020
300			_a44-50p.
520			_aA simple, specific, precise and robust method for the estimation of emtricitabine, bictegravir and tenofovir alafenamide in the presence of impurities was developed and validated. The separation was performed on Aquity UPLC system with SB C8 50 x 2.1 mm, 1.7μ column under isocratic elution mode. The components were eluted using 0.01 N phosphate buffer and acetonitrile in the ratio of 50:50 V/V and detected at UV wavelength of 272 nm. The retention times were found to be 1.017 min, 1.484 min and 1.864 min for emtricitabine, bictegravir and tenofovir alafenamide, respectively. The developed method was validated as per ICH guidelines. The method was stable and specific and when the sample was stressed under different conditions (acid, base, peroxide, photolytic, neutral, no interference of degradants were observed.
650		0	_94639 _aPHARMACEUTICS
700			_912307 _aGowri Sankar, D.
773	0		_dMumbai Indian Drug Manufactures Association _tIndian drugs
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=MTAxMw== _yClick here
942			_2ddc _cAR