000			a
999			_c13780 _d13780
003			OSt
005			20201207120009.0
008			201207b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912705 _aParveena, A.
245			_aIn vitro and in silico Analysis to Identify Novel Lead Compound from Morinda tinctoria fruit Against Breast Cancers
250			_aVol.51(5), Sep-Oct
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a970-975p.
520			_aIn the present study, the anticancer activity of Morinda tinctoria fruit extract was evaluated in vitro and in silico. The ethanol extract of the fruit was prepared and subjected to preliminary screening and gas chromatography-mass spectrometry analysis to identify phytochemical constituents. Free radical scavenging activity of Morinda tinctoria fruit extract was evaluated using 2,2’-azinibis(3- ethylbenzothiazoline-6-sulfonic acid and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Morinda tinctoria fruit extract at 125 μg/ml concentration inhibited the growth of MDA-MB cell lines. The drug likenesses property of compounds present in the ethanol extract was analysed based on Lipinski’s rule of five. The breast cancer protein ErBb2 was chosen as target for studying the molecular interaction with selected ligands. Corynan-17-ol,18,19-didehydro-10-methoxy was selected as an efficient lead molecule against target-based on the lowest binding energy value of –5.9 Kcal/mol. This showed that the fruit of Morinda tinctoria could be explored to identify promising lead molecules against breast cancer.
650		0	_94639 _aPHARMACEUTICS
700			_912706 _aArthi, S.
773	0		_dNew Delhi Indian Pharmaceutical Association _tIndian journal of pharmaceutical sciences _x0250-474X
856			_uhttps://www.ijpsonline.com/articles/iin-vitroi-and-iin-silicoi-analysis-to-identify-novel-lead-compound-from-imorinda-tinctoriai-fruit-against-breast-cancer.pdf _yClick here
942			_2ddc _cAR