| 000 | a | ||
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_c13809 _d13809 |
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| 003 | OSt | ||
| 005 | 20201215093835.0 | ||
| 008 | 201215b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_912756 _aMondal, R. |
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| 245 | _aDevelopment and Characterization of a Phospholipid Complex for Effective Delivery of Capsaicin | ||
| 250 | _aVol.81(6), Nov-Dec | ||
| 260 |
_aMumabi _bIndian Journal of Pharmaceutical Science _c2019 |
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| 300 | _a1011-1019p. | ||
| 520 | _aCapsaicin is responsible for the chili’s pungent flavour and is used to suppress different types of cancer cells. However, capsaicin causes gastrointestinal irritation and shows poor aqueous solubility. To increase the aqueous solubility and decrease the gastrointestinal irritation, capsaicin was complexed with phospholipid. A phospholipid complex was prepared and characterized through x-ray diffraction, differential scanning calorimetry, and Fourier-transform infrared spectroscopy. The prepared phospholipid complexes were studied for solubility, in vitro drug release and in vitro cytotoxicity. Molecular interaction between capsaicin and phospholipid was identified through Fourier-transform infrared spectroscopy, which confirmed the formation of phospholipid complex. X-ray diffractometer and differential scanning calorimetry results indicated reduced crystallinity of capsaicin in the complex. The solubility of the capsaicin was found to be enhanced 1.7 and 2.6 fold in 1:1 and 1:2 complex in comparison to free capsaicin. In dissolution studies, the phospholipid complex exhibited a higher rate of drug release compared to the free drug. Phospholipid complex showed more cytotoxic potential on MCF-7 and MDA-MB-231 human breast cancer cells compared to free capsaicin in an MTT assay that measures metabolic activity. The present study demonstrated that a phospholipid complex of capsaicin overcomes the problems related to the poor aqueous solubility and could be used as effective delivery carrier for cancer therapy. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_912757 _aBobde, Y. |
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| 773 | 0 |
_dNew Delhi Indian Pharmaceutical Association _x0250-474X _tIndian journal of pharmaceutical sciences |
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| 856 |
_uhttps://www.ijpsonline.com/articles/development-and-characterization-of-a-phospholipid-complex-for-effective-delivery-of-capsaicin.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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