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| 999 |
_c13811 _d13811 |
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| 003 | OSt | ||
| 005 | 20201215095515.0 | ||
| 008 | 201215b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_912760 _aGui, J. S. |
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| 245 | _aModulation of NOX4 and MAPK Signalling Pathways by Parkia speciosa Empty Pods in H9c2 Cardiomyocytes Exposed to H2O2 | ||
| 250 | _aVol.81(6), Nov-Dec | ||
| 260 |
_aMumbai _bIndian Journal of Pharmaceutical Science _c2019 |
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| 300 | _a1029-1035p. | ||
| 520 | _aParkia speciosa, a plant that grows abundantly in Southeast Asia region, has been reported to exhibit antioxidant property. This study aimed to investigate the mechanism of antioxidant effects of empty pod extract of Parkia speciosa on hydrogen peroxide-induced oxidative stress in H9c2 cardiomyocytes. There were 4 groups of cardiomyocytes, the negative control, hydrogen peroxide, extract of Parkia speciosa+hydrogen peroxide and quercetin+hydrogen peroxide. Cardiomyocytes of groups 3 and 4 were preincubated for 1 h with 500 μg/ml of the ethyl acetate fraction of the Parkia speciosa extract or 1000 μM quercetin prior to exposure to 500 μM hydrogen peroxide for 1 h. Hydrogen peroxide significantly increased the protein expression of NADPH oxidase 4, superoxide dismutase 1 and p38 mitogen-activated protein kinase, in comparison to the negative control. NADPH oxidase 4 and superoxide dismutase 1 activities as well as reactive oxygen species level were also elevated. These elevations were significantly decreased in the pretreated groups. The Parkia speciosa extract group had comparable effects to that of quercetin. Parkia speciosa extract showed antioxidant property against hydrogen peroxide-induced oxidative stress in H9c2 cardiomyocytes by regulating mitogen-activated protein kinase and NADPH oxidase 4 signalling pathways | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_912761 _aMustafa, N. H. |
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| 773 | 0 |
_tIndian journal of pharmaceutical sciences _dNew Delhi Indian Pharmaceutical Association _x0250-474X |
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| 856 |
_uhttps://www.ijpsonline.com/articles/modulation-of-nox4-and-mapk-signaling-pathways-by-iparkia-speciosai-empty-pods-in-h9c2-cardiomyocytes-exposed-to-h2o2.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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