000			a
999			_c13839 _d13839
003			OSt
005			20201221104047.0
008			201221b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912816 _aRamya, A. R.
245			_aDesign and Evaluation of a Self-Emulsifying Drug Delivery System of Aripiprazole
250			_aVol.81(6), Nov-Dec
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a1089-1098p.
520			_aThe present investigation is aimed at enhancing the solubility and the dissolution rate of aripiprazole by formulating a self-micro emulsifying drug delivery system. The preliminary solubility screening of aripiprazole was determined in oils, surfactants and cosurfactants, respectively. Among those screened, isopropyl myristate, Tween 80 and propylene glycol showed good solubilizing efficiency and were selected for further formulations. A pseudoternary phase diagram was constructed at the ratios of 2:1, 3:1, 4:1 of oil to Smix (surfactant:Tween 80) and cosurfactant (propylene glycol) to find out the self-emulsification region. In vitro dissolution studies of the formulations were carried out in a simulated acidic buffer pH 2.2. A liquid self-micro emulsifying drug delivery system with an optimum composition was converted to solid formulation using crospovidone. Both solid and liquid formulations were evaluated for the cloud point and self-emulsification time. Differential scanning calorimetry endotherm provided confirmation for the amorphisation of the drug. Zeta potential and particle size analysis was carried out on the optimized formula. These studies revealed that the prepared self-micro emulsifying drug delivery system exhibited increased dissolution rate profile in comparison to the pure drug and marketed aripiprazole tablets.
650		0	_94639 _aPHARMACEUTICS
700			_912817 _aPreethi, Sudheer
773	0		_tIndian journal of pharmaceutical sciences _dNew Delhi
856			_uhttps://www.ijpsonline.com/articles/design-and-evaluation-of-a-selfemulsifying-drug-delivery-system-of-aripiprazole.pdf _yClick here
942			_2ddc _cAR