000			a
999			_c13843 _d13843
003			OSt
005			20201221110843.0
008			201221b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_912824 _aSmerikarova, M.
245			_aDevelopment and Validation of a RP-HPLC Method to Quantify Amoxicillin, Tinidazole, Esomeprazole and Lan-soprazole in a Mixture
250			_aVol.81(6), Nov-Dec
260			_aMumbai _bIndian Journal of Pharmaceutical Science _c2019
300			_a1122-1127p.
520			_aPresent investigation dealt with the developing of a reversed phase-high performance liquid chromatographic method for determination of amoxicillin, tinidazole, esomeprazole and lansoprazole in pure state and as a mixture. Chromatographic separation was performed isocratically on a LiChrospher® 100 RP-18 column. The flow rate was 1.0 ml/min and the detector was set at 280 nm. The method was developed at ambient temperature with a mobile phase, 40:60 v/v acetonitrile and phosphate buffer (0.001 M, pH 7.6). The selected conditions were applicable for separating amoxicillin, tinidazole, esomeprazole and lansoprazole with retention times 3.11, 5.37, 11.71 and 17.67 min, respectively. The method was validated for parameters including linearity, selectivity, precision and accuracy, limit of detection and limit of quantitation. Linear calibration curves were obtained in the concentration range of 250.0-2000.0, 125-1000.0, 5.0-40.0 and 7.5-60.0 μg/ml for amoxicillin, tinidazole, esomeprazole and lansoprazole, respectively. The proposed method was found to be effective and could be used for quantification of these drugs in routine quality control practice.
650		0	_94639 _aPHARMACEUTICS
700			_912825 _aBozhanov, S.
773	0		_tIndian journal of pharmaceutical sciences _dNew Delhi
856			_uhttps://www.ijpsonline.com/articles/development-and-validation-of-a-rphplc-method-to-quantify-amoxicillin-tinidazole-esomeprazole-and-lansoprazole-in-a-mixt.pdf _yClick here
942			_2ddc _cAR