000			a
999			_c15522 _d15522
003			OSt
005			20211120140058.0
008			211120b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_914689 _aI'tishom, Reny
245			_aOral Delivery of Purple Sweet Potato (Ipomoea batatas L.) Extract-Loaded Carboxymethyl Chitosan and Alginate Nanocapsule in Streptozotocininduced Diabetic Mice
250			_aVol.55(3), Jul-Sep
260			_aBanagalore _bAssociation of Pharmaceutical Teachers of India (APTI) _c2021
300			_a709-714p.
520			_aBackground: Insulin therapy is an essential part in diabetes mellitus type 2 treatment, but it has several side effects such as allergy and hypoglycemia. Therefore, alternative treatments are needed, one of which is by using nanocapsules to increase the performance of the drug delivery system. Purple sweet potato contain high anthocyanin levels which has antidiabetic properties. The idea of this research were to determine the potential use of purple sweet potato extract-loaded CMC-Alginate nanocapsules and to address problems regarding the efficiency of encapsulation to increase the bioavailability. Methods: This experimental research used post-test only control group design. The samples were 24 mice which were separated into four groups based on the administration of the following, respectively: 0.5 mL of extract-containing CMC-Alginate nanocapsules, 0.5 mL of extract, 1 mL of glibenclamide as the positive control and 0.5 mL of 0.5% CMC sodium placebo as the negative control. Mice were conditioned to be diabetic by induction of Streptozotocin. Blood glucose levels were carried out on days 1, 3, and 7 using an “Easy Touch” glucometer. The statistical analysis was conducted by two-way ANOVA proceeded by Tukey’s post hoc test to investigate the differences between all groups. Results: Statistically, purple sweet potato extract-loaded CMCAlginate nanocapsules, which its extract concentration was 4.4 times less than that of extract without encapsulation, can reduce high glucose levels in mice when as compared to negative control (p<0.05). Conclusion: Purple sweet potato extract-loaded CMCAlginate nanocapsules has capability to reduce blood glucose levels of streptozotocininduced mice.
650		0	_94639 _aPHARMACEUTICS
700			_914690 _a Wafa, Ifan Ali
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-55-3-709.pdf _yClick here
942			_2ddc _cAR